Abstract
Azithromycin, an antibiotic used to treat bacterial infections, was labeled with 99mTc. The maximum radiochemical yield of 99mTc-azithromycin, 97.5 ± 0.9%, was attained under the following conditions: addition of 99mTc to 2 mg of azithromycin in the presence of 50 μg of SnCl2·2H2O at pH 4, reaction time 30 min. 99mTc-azithromycin complex was stable for 6 h. Biological distribution of 99mTc-azithromycin was studied in mice infected with Staphylococcus aureus in the left thigh. The ratio of 99mTc-azithromycin uptake in the bacterially infected and contralateral thighs, T/NT, for was found to be 6.20 ± 0.12 at 2 h after intravenous injection (higher than the ratio obtained with the commercially available 99mTc-ciprofloxacin), which was followed by gradual decline. The results obtained show that 99mTc-azithromycin can be used for infection imaging and allows differentiation between bacterial infection and sterile inflammation.
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