Abstract
Loss of immune cell function, increased myeloid cell output, and increased incidence of myeloproliferative neoplasms all characterize aged hematopoiesis. Studies have shown that many of these characteristics are due to the aging hematopoietic stem cell (HSC) compartment. The HSC compartment consists of discreet subsets of HSCs that differ in their differentiation potential, and HSCs with myeloid-biased output accumulate in aged individuals contributing to increased myeloid cell production. Additionally, phenotypic HSCs are known to accumulate in the aged but demonstrate functional defects in homing and repopulation after transplantation.
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