Abstract
The timely discovery of cancer cell resistance in clinical processing and the accurate calculation of drug dosage to reduce and inhibit tumour growth factor in cancer patients are promising technologies in cancer therapy. Here, an optofluidic resonator effectively detects drug interactions with cancer cell processing in real time and enables the calculation of label-free drug-non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) and binding ratios using molecular fluorescence intensity. According to clinical test and in vivo experimental data, the efficiencies of gefitinib and erlotinib are only 37% and 12% compared to AZD9291, and 0.300 μg of EGFR inactivation requires 0.484 μg of AZD9291, 0.815 μg of gefitinib and 1.348 μg of erlotinib. Experimental results show that the present method allows for the performance detection of drug resistance and for the evaluation of dosage usage.
Highlights
Erlotinib and gefitinib tyrosine kinase inhibitors (TKIs) were serendipitously found to be the most effective in advanced non-small cell lung cancer (NSCLC) clinical development [1]
Experiment results have proved that optofluidic resonators provide an effective way to detect drug interactions in real time using epidermal growth factor receptor (EGFR) and cancer cells process with CCD real-time monitoring of attenuated total reflection (ATR) shifts
By comparing the gefitinib and erlotinib ATR dip synchronized angles, we can observe that the NSCLC-EGFR molecular structure significantly changed by injecting AZD9291, and the θ shifted 0.160 degrees from 0 s to 60 s
Summary
Erlotinib and gefitinib tyrosine kinase inhibitors (TKIs) were serendipitously found to be the most effective in advanced NSCLC clinical development [1]. Preclinical modeling and analysis of tumor tissue obtained from patients in the study of the disease have been employed Such genetic technology [19,20,21,22,23,24,25] has led to the identification of a number of mechanisms that mediate EGFR TKI resistance. Investigation of the mode power distribution suggests us to design a configuration that contains the sample in the guiding layer of the waveguide, where oscillating wave is located and most of the mode power concentrates Addressed this issue, a hollow-core metal-cladding optofluidic resonator is developed to carry out the experiment [33]. Experiment results have proved that optofluidic resonators provide an effective way to detect drug interactions in real time using EGFR and cancer cells process with CCD real-time monitoring of ATR shifts
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