Abstract
A sensitive, selective and recyclable electrochemical sensor is designed for ATP detection based on amino-functionalized metal-organic framework. The functional MOF as the sensor is constructed by one-step synthesis Ce-MOF and sequentially modified on the Au electrode and conjugated with the aptamer of ATP. The presence of target ATP leads to the conformational change of aptamer strands and strong electrochemical impedance. The electrochemical sensor can detect ATP down to 5.6 nM with the linear range of 10 nm to 1000 μM. The present study is the first report on the use of MOF as an electrochemical sensor for ATP at nM level. This strategy has been successfully applied in detection of ATP in serum of cancer patients, which reveals its potential application in clinical diagnosis.
Highlights
Metal-organic framework (MOF), a promising class of multifunctional materials, has always been received extensive attention since 199921
The convenient method can detect Adenosine triphosphate (ATP) at nanomolar level. It is the first report of MOF-based electrochemical sensor for the detection of ATP
This strategy has been successfully applied in detection of ATP in serum of cancer patients, which reveals its potential application in clinical diagnosis
Summary
Metal-organic framework (MOF), a promising class of multifunctional materials, has always been received extensive attention since 199921. Lei’s group reported a electrochemical biosensor based on the Pt@UiO-66NH2, in which the Pt@UiO-66-NH2 was immobilized with capture DNA as a signal probe for detecting the telomerase activity in cancer cells[31]. It is not hard to find that most MOFs-based electrochemical biosensors are combined with metal NPs or post-modified functional groups, which increase the experimental complexity. The convenient method can detect ATP at nanomolar (nM) level It is the first report of MOF-based electrochemical sensor for the detection of ATP. This strategy has been successfully applied in detection of ATP in serum of cancer patients, which reveals its potential application in clinical diagnosis
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