Abstract
Baclofen is a structural analogue of GABA, used in the treatment of muscle spasticity that has seen its use expanded since 2008 in the treatment of alcohol addiction. With much higher dosage for this indication, overdose in treatment and acute intoxications are responsible of neurological disorders that can lead to a life-threatening prognosis. Management is essentially symptomatic and usually performed in hospital.The pharmacokinetic properties of baclofen explain the risk of its accumulation, as well as its “dialysable” characteristics useful in the management of an overdose in renal failure. In a much less well-known way, baclofen is at the origin of a risk of withdrawal.In these different situations, elimination monitoring of the drug can be carried out by its plasma and urinary assays in specialised toxicology laboratories. This monitoring can be used to assess the effectiveness of a scrubber treatment. Plasma concentrations in cases of acute intoxications are described in the literature between 700 and 3 300 ng/mL.No automated screening test is available to determine baclofen. Currently, the only methods for its identification and determination are targeted methods more commonly described in liquid chromatography coupled with mass spectrometry.
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