La Substitution Nucléophile Activée en Série Aromatique V. Réactivité Des 2‐, 3‐ et 4‐ Chloropyridine N‐Oxydes Avec la Piperidine dans le Méthanol

Abstract

AbstractThe rates of reaction of 2‐, 3‐ and 4‐chloropyridine N‐oxides towards 1 M piperidine in methanol have been measured conductimetrically. Apparent unimolecular rate constants at 80°C are respectively 3,70.10−4, 1,04.10−7 and 1,02.10−4 sec−1. The reactivity sequence 2 > 4 >> 3 is discussed in terms of competing inductive and “built‐in solvation” effects.