Abstract
Resistance to antifungal drugs : importance in human and veterinary medicine. Infections caused by pathogenic fungi are a significant global problem : a situation exacerbated by the limited availability of antifungal options, especially in veterinary Medicine. Like other microorganisms, fungi exist in populations that are adaptable. Under the selection pressure by antifungal drugs, drug-sensitive fungal populations frequently evolve resistance. Antifungal drug resistance appears to essentially be due to point mutations in either drug targets or transcription factors. Phenotypic methods for identification of antifungal resistance should be considered as reliable procedures, and the determination of minimum inhibition concentrations (MIC) by reference techniques is the gold standard to detect resistant clinical isolates. This text reviews the present state of the detection of resistance in fungal pathogens (Malassezia pachydermatis, Cryptococcus spp. and Aspergillus fumigatus) and its relevance to clinical practice in veterinary Medicine.
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