La importancia de los auto- anticuerpos IGG específicos tipo II en la enfermedad de MENIERE y pérdida progresiva de la audición

Abstract

The Meniere's Disease and Progressive Hearing Loss were considered idiopathic. Both entities were produced by endo lymphatic hydrops and disruption of the membrane which contain type II collagen. The inner ear presented widely expression of type II collagen. These pathologies were probably autoimmune diseases.The aim of this work was to study the relationship of specific IgO to type II collagen in Meniere's disease, Progressive hearing loss, and compared with Sudden hearing loss patients, vascular vertigo patients and normal controls. Patients were divided by clinical findings in: 1° Meniere's disease (n:27), 2° Progressive Hearing loss (n:20), 3° Sudden hearing loss (n: 15), 4° Vascular Vertigo (n:9) and compared with normal controls (n:30) aged and sex matched. Wc have measured specific IgG to type II collagen by ELISA test. We considered positive the OD two or more SD aboye the mean of normal controis. Results: 1° The Meniere's group presented IgG to type II collagen (+) in'.)'.) out of 27 patients, p<.025; 20 The Progressive Hearing loss presented 1gG to type II collagen in alt cases (n:20), p<.0005. The Sudden Hearing loss presented 1gG to type II collagen(-) in alt cases (n:15) p<.00001 and Vascular Vertigo (n:9) presented IgG to type II collagen (-) in 8 out of 9 cases, p<,0005. These results suggest strongly the notion that Meniere's diseases and Progressive hearing loss have specific IgG to type II collagen and these conditions were ascribed with in autoimmune process.