Abstract
Multiple pregnancies are the main complication associated to assisted reproduction, due to the transfer of more than one embryo. Embryo cryopreservation allows the sequential transfer of all generated embryos, thus diminishing the risk of multiple pregnancies. However, it leads to accumulation of cryopreserved embryos. To reduce their accumulation in our unit, we started to preserve embryos as blastocysts, that have a rate of successful pregnancies of approximately 40%.To perform a sensitivity analysis of this change of policy on the accumulation of embryos.Records of 571 cycles of in vitro fertilization since 2007 were reviewed, assuming a transference rate of two embryos in women aged less than 35 years and three embryos in older women. The number of embryos that would be preserved as zygotes, eight cell stage or blastocysts, was analyzed.Multiple component logistic regression analysis showed a 20% reduction in the odds ratio of cryopreservation per year of age. There was a 95% reduction in the ratio, when comparing the preservation of third and first day embryos and a 99% reduction when comparing preservation of embryos in blastocyst stage and first day embryos.Cryopreservation at blastocyst stage effectively decreased the frequency of embryo cryopreservation.
Highlights
Cryopreservation in blastocyst stage effectively reduce the number of embryos cryopreserved Background: Multiple pregnancies are the main complication associated to assisted reproduction, due to the transfer of more than one embryo
Muchas parejas tienen varios embriones criopreservados pero con mínimo potencial implantatorio, ya que los mejores embriones de la cohorte ya fueron transferidos
La mediana de embriones criopreservados es similar en los grupos de mujeres más jóvenes, pero menor en el grupo de mujeres ≥ 40 años
Summary
Revisamos todos los casos de fertilización in vitro (con o sin inyección intracitoplasmática de espermatozoides) entre el 1 de enero de 2007 y el 30 de junio de 2010, e hicimos un análisis de sensibilidad, asumiendo la transferencia de un máximo de dos embriones en mujeres menores de 35 años, y un máximo de tres embriones en mujeres con 35 y más años[3,4]. Analizamos 571 casos consecutivos de ciclos de fertilización in vitro (con o sin inyección intracitoplasmática de espermatozoides) en los que al menos fecundó un ovocito. La Tabla 2 muestra los resultados del análisis de sensibilidad, en que se muestra la frecuencia de parejas que criopreservarían embriones de acuerdo al estadio de desarrollo embrionario en el que se criopreservan los embriones. A medida que avanza el estadio elegido para criopreservar desde
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