Abstract
BackgroundL1 cell adhesion molecule (L1CAM) and epithelial cell adhesion molecule (EPCAM) have been implicated in the development and progression of gastric cancer. The present study investigated the clinical significance of L1CAM and EPCAM in the development, progression and prognosis of gastric cancer.MethodsExpression of L1CAM and EPCAM were examined immunochemically in 601 clinicopathologically characterized gastric cancer cases.ResultsL1CAM protein was detected in 23.9% of human non-tumor mucosa samples. All samples expressed L1CAM protein at low levels. High expression of L1CAM protein was detected in 163 (27.1%) tumors. Expression of L1CAM correlated with age, tumor location, size of tumors, Lauren’s classification, depth of invasion, lymph node and distant metastases, regional lymph node stage, Tumor-Node-Metastasis (TNM) stage and prognosis. EPCAM protein was detected in 45.7% of human non-tumor mucosa samples. All samples expressed EPCAM protein at low levels. High expression of EPCAM protein was detected in 247 (41.1%) tumors. Expression of EPCAM correlated with age, tumor location, size of tumors, Lauren’s classification, depth of invasion, lymph node and distant metastases, regional lymph node stage, TNM stage and prognosis. Cumulative 5-year survival rates of patients with high expression of both L1CAM and EPCAM were significantly lower than in patients with low expression of both.ConclusionsExpression of L1CAM and EPCAM in gastric cancer was significantly associated with lymph node and distant metastasis, and poor prognosis. L1CAM and EPCAM proteins could be useful markers to predict tumor progression and prognosis.
Highlights
Global incidence of gastric cancer has decreased in recent years, its mortality rate in China is the highest among all tumors
Expression of L1 cell adhesion molecule (L1CAM) and epithelial cell adhesion molecule (EPCAM) mRNA in gastric tumor tissue and cell lines L1CAM and EPCAM mRNA were significantly upregulated in AGS, MKN-28, BGC-823, HCG-27, SGC
L1CAM was over-expressed in 25 gastric tumor tissue samples compared with matched normal gastric mucosa
Summary
Global incidence of gastric cancer has decreased in recent years, its mortality rate in China is the highest among all tumors. The main cause of death is invasion and metastasis of tumor. Tumor invasion and metastasis is a very complicated and continuous process involving multiple steps, regulated at the molecular level by limited to cell adhesion; they include diverse processes such as signaling, cell migration, proliferation, and differentiation. The current study examined expression of L1CAM and EPCAM in surgical specimens of gastric carcinoma, to explore possible correlations between L1CAM and EPCAM expression and clinicopathological variables and prognosis. L1 cell adhesion molecule (L1CAM) and epithelial cell adhesion molecule (EPCAM) have been implicated in the development and progression of gastric cancer. The present study investigated the clinical significance of L1CAM and EPCAM in the development, progression and prognosis of gastric cancer
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