Abstract
Thalamocortical neurons integrate sensory and cortical activity and are regulated by input from inhibitory neurons in the thalamic reticular nucleus. Evidence suggests that during bursts of action potentials, dendritic calcium transients are seen throughout the dendritic tree of thalamocortical cells. Here, we review a recent study that suggests these calcium transients regulate inhibitory input, and we attempt to reconcile studies that differ on which ion channels are the source of the calcium.
Highlights
THE THALAMUS IS A CRITICAL relay and processing station for a wide variety of neural signals
When cells were held at approximately Ϫ60 mV, 60 pairings at 0.1 Hz of evoked inhibitory postsynaptic potentials (IPSPs) with two current injection-induced action potentials produced an ϳ50% potentiation of IPSP amplitude, which lasted for the length of the recording
The relative timing of the IPSP and the pair of action potentials did not affect the magnitude of the potentiation, and, importantly, postsynaptic spiking alone was sufficient to induce iLTP
Summary
THE THALAMUS IS A CRITICAL relay and processing station for a wide variety of neural signals. L-type calcium channel-dependent inhibitory plasticity in the thalamus.
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