Abstract
We have demonstrated (Saito et al., 1986) that in isolated rat hepatocytes, L-tryptophan (Trp) uptake occurs via at least two saturable transport systems [one high-affinity (Km = 14 μM) and one low-affinity (Km = 2.1 mM)] and one non-saturable one. It has also been shown (Saito et al., 1990; Ohta et al., 1992) that the activity of Trp uptake via the high-affinity transport system into hepatocytes increases in rats with induction of liver tryptophan 2,3-dioxygenase (TDO) by Trp or cortisone treatment, while that uptake activity decreases in rats with depression of liver TDO activity by chronic nicotinamide administration. These findings have suggested that liver Trp uptake via the high-affinity transport system is closely related to liver Trp metabolism via TDO in rats.KeywordsNormal DietKynurenine AminotransferaseSaturable Transport SystemLiver TryptophanCytosolic Aspartate AminotransferaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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