Abstract
AbstractA new protocol for the synthesis of thieno[3,2-c]coumarins is disclosed. In this method, a 3-formyl-2-oxo-2H-chromene-4-thiolate anion is generated in situ by treatment of 4-chloro-3-formylcoumarin with sodium sulfide. This chromene-4-thiolate undergoes an l-proline-catalyzed substitution/Knoevenagel cascade with various α-halo ketones to afford the desired thienocoumarins in moderate to good isolated yields. This protocol eliminates the need for stoichiometric amounts of inorganic bases and the use of foul-smelling thiols. The reaction conditions tolerate a variety of α-halo ketones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
