Abstract
Hypercosinophilia was previously considered as a biological marker, particularly useful for diagnostic investigation. However, it can also appear as a marker of disease activity since fundamental studies have revealed the potent pathogenic role of human eosinophils. This new appreciation is related to a better definition of the molecular and cellular basis of eosinophil functions. Thus, eosinophils were identified as inflammatory and/or cytotoxic cells after the characterization of the role of surface molecules (adhesion molecules, Fc receptor of immunoglobulins) and mediators. The molecular components which endow the eosinophil with certain of its functional characteristics are primarily the cationic proteins of the specific granules and the phospholipid mediators that are newly formed during cellular activation. Some of these effector molecules are also directly involved in the induction of deleterious effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
