Abstract
We report that, contrary to expectations, the administration of the potent NO-synthesis inhibitor L-N G -nitro arginine (LNA) produces a markedly exaggerated hypertensive response in urethane-anesthetized SHR as compared to age-matched Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats. Since the resting ABPs and baroreceptor reflex activities of these strains were approximately equal under urethane anesthesia, the present results suggest that the synthesis/release or biological activity of EDRF may actually be enhanced in the SHR and that this vasodilator may modulate the expression of hypertension in this strain
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