Abstract
The repairin vitro of long bones after experimental injury was studied and influenced with bone extract (Ossopan). The explants were cultivated by the watch-glass method in a medium of chick-plasma and embryonic extract, varying the culture time from 1 to 12 days. The bones cultivated on the above medium with addition of bone extract, showed a greater number of cells in general and particularly in the region of the callus. Osteoblasts appeared as early as the fourth day. The early appearance and quantity of the periostal osteoid tissue was striking. By the eigth day, the repair in the treated bones became slower, while the callus formation in the uninfluenced bones progressed normally. Generally the bone-continuity was more or less restablished on the tenth day. These experiments prove the clear influence of bone extract on activation of bone healing during the first 8 days following explantation.
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