Abstract
Introduction The non-dependant food hypersensitivity as described by Gell and Coombs has its interest on the immunological plan. The studies that the authors have lead since many years permitted to evoke a link between the non IgE-dependent hypersensitivity to milk cow proteins and a certain digestive and non digestive symptomatology in children as colic, gastro-oesophageal reflux, constipation, eczema, sleep disorders, vulvitis in young girls, chronic fatigue, or serous otitis. The authors wanted to study if there is a link between this etiology and the hyperactivity in children. Observation Fifteen infants, eight girls and seven boys aged between 18 month and 6 years old, had consulted for permanent diurnal hyperactivity associated to other non specific symptoms or signs as eczema, sleep disorders, somnambulism, stammer, constipation or abdominal pain. The history of first year of life reveal symptoms as colic, gastro-œsophageal reflux, recurrent bronchitis, eczema and sleep disorders. The suppression of milk and the preservation of a small quantity of fermented milk products lead to a decrease of hyperactivity within 48 hours in 13 cases. The suppression of all milk products in the non-responders (2/15 cases) attenuated their symptoms. The reintroduction of milk in their alimentation reproduced the same previous symptoms within 48 hours. The immunological tests showed positive results for non IgE-dependent hypersensitivity to milk cow proteins. Discussion The different responses of the organism facing an antigen that it is alimentary or not suggest a link between non IgE-dependent hypersensitivity to milk cow proteins and hyperactivity in infants having a digestive or non digestive symptomatology during the first year of life. The symptomatology might be induced by immunological mechanism that it is due the immune complexes depot effect, a cellular mediation or by other unknown mechanisms.
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