L-histidine induced changes in adenosine 3′:5′-monophosphate levels in rat brain and amounts of apo-, holo- [formula omitted] and holo- [formula omitted] fatty acid synthetases in rat liver

Abstract

When fasted rats were fed a chow or fat-free diet supplemented 5% with L-histidine for three days, the brain adenosine 3′:5′-monophosphate (cAMP) level increased. A 50% increase occurred in rats fed a chow diet and 20% increase in rats fed a fat-free diet. Purification of liver fatty acid synthetase and the isolation of liver apo-, holo- a and holo- b fatty acid synthetases demonstrated that L-histidine feeding caused changes in the relative amounts of these enzymes. Apo- and holo- b fatty acid synthetases increased while the holo- a form simultaneously decreased. This effect was observed in rats fed either chow or fat-free diets supplemented with L-histidine.