L-HetNetAligner: A novel algorithm for Local Alignment of Heterogeneous Biological Networks

Abstract

Networks are largely used for modelling and analysing a wide range of biological data. As a consequence, many different research efforts have resulted in the introduction of a large number of algorithms for analysis and comparison of networks. Many of these algorithms can deal with networks with a single class of nodes and edges, also referred to as homogeneous networks. Recently, many different approaches tried to integrate into a single model the interplay of different molecules. A possible formalism to model such a scenario comes from node/edge coloured networks (also known as heterogeneous networks) implemented as node/ edge-coloured graphs. Therefore, the need for the introduction of algorithms able to compare heterogeneous networks arises. We here focus on the local comparison of heterogeneous networks, and we formulate it as a network alignment problem. To the best of our knowledge, the local alignment of heterogeneous networks has not been explored in the past. We here propose L-HetNetAligner a novel algorithm that receives as input two heterogeneous networks (node-coloured graphs) and builds a local alignment of them. We also implemented and tested our algorithm. Our results confirm that our method builds high-quality alignments. The following website *contains Supplementary File 1 material and the code.