Abstract
Acetylcholine (ACh) release was measured by microdialysis. Addition of 10 nM l-DOPA to the perfusate significantly decreased ACh release, from the striatum of rats lesioned with 6-hydroxydopamine (6-OHDA), but not sham-operated rats. The l-DOPA-induced decrease was not affected by (−)-sulpiride which completely blocked D 2- and D 3-agonist-induced decrease in ACh release in lesioned rats. Neither 10 nM d-DOPA nor 100 nM dopamine caused any change in ACh release. These findings suggest that l-DOPA-sensitive mechanisms are supersensitized in Parkinson's disease model rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
