Abstract
Aims: Long-term L-DOPA treatment can induce severe dyskinesia in patients with PD. In the rat PD model, repeated pulsatile administration of L-DOPA progressively induces involuntary movements, which resemble L-DOPA-induced dyskinesia in patients with PD. However, all dyskinesia studies in the rat PD model have exclusively been performed in animals with unilateral dopamine-denervating lesions, i.e. animals showed involuntary movements only on one side of the body. We have therefore performed a study in rats with bilateral dopamine-denervating lesions.
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