Abstract
Cytoplasmic fragmentation may be present in the in-vitro cultured embryos. This fragmentation may arise from apoptosis. Apoptosis is associated with changes in the mitochondrial membrane potential. Recent studies show that ooplasmic injection of isolated mitochondria can rescue oocyte fragmentation in mice. L-Carnitine (LC) is able to stabilize the mitochondrial membranes potential, increase the supply of energy and protect the cell from apoptotic death. In a pilot study we have shown that L Carnitine can improve the blastocysts development rate (%BDR) in 2-cell embryos at low concentrations (0.3 mg/ml).
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