L’association cancer du sein et cancer de la thyroïde : quelle relation ?

Abstract

ObjectivesTo assess the prevalence of breast cancer in patients followed for differentiated thyroid cancer in the nuclear medicine department of Ibn Sina university hospital and compare with data from the literature and the prevalence breast cancer in the general population. Identify the group of patients with a high risk of developing multiple primary cancers syndrome involving both cancers through the data in the literature and through the study of different epidemiological, histological and therapeutic aspects of our patients. Materials and methodsIn this work, we report the case of patients who experienced a differentiated thyroid cancer after breast cancer. The file review examined the history of the patients, histological type and treatment history for breast cancer, free interval between the diagnosis of breast cancer and the thyroid cancer and histological type of thyroid cancer. ResultsTen women with an age range between 35 and 68 who all had external beam radiation and chemotherapy for the treatment of breast cancer. The time to onset of thyroid cancer varied between 4 months and 22 years with a mean of 5.6 years, 60% had evidence for a genetic predisposition to cancer. DiscussionPatients with a potential to have thyroid cancer and breast cancer combined, according to our results and those of several studies are female patients who had the first cancer at a young age (under 45) and epidemiological characteristics suggesting a hereditary cancer. ConclusionPending confirmation of these results still preliminary, several authors recommend greater vigilance regarding the early detection of thyroid cancer in patients followed for breast cancer and vice versa.