Abstract
Local antibiotic therapy is effective in acute infectious conjunctivitis Ten years after the last Cochrane review on the subject, this small randomized trial (88 participants aged 6 months to 7 years) aimed to test the efficacy of local antibiotic therapy (moxifloxacin) vs placebo in acute infectious conjunctivitis. To exclude the possible benefit related to the washout effect of placebo drops, a second control group with no treatment was included. Clinical healing time was significantly shorter in the moxifloxacin group than in the non-intervention group (3.8 vs. 5.7 days). An additional analysis was performed on the 2 control groups from which a shorter clinical healing time was found for placebo drops compared with no treatment; however, the difference was not statistically significant. The study was included in a meta-analysis with 3 previous studies comparing antibiotic therapy versus a control group with no antibiotic for the treatment of acute conjunctivitis in children aged 1 month to 18 years, with substantial confirmation of the already known results.
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