Abstract
l-5-Hydroxytryptophan (l-5-HTP)-induced flat body posture (FBP) was antagonized by ritanserin in doses that were lower than those needed to antagonize head-twitches (HTW) and forepaw treading (FPT). 5,7-Dihydroxytryptamine (5,7-DHT) potentiated l-5-HTP-induced FBP but not HTW or FPT. Ritanserin interacted with 5-HT 2 and 5-HT 1c receptors. l-5-HTP-induced FBP could be mediated by postsynaptic 5-HT 1c receptors and could serve as a behavioral model of postsynaptic 5-HT 1c receptor stimulation in the CNS.
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