Kyrle’s Disease: A Case Report and Literature Review

Abstract

BACKGROUND: Perforating dermatoses are heterogeneous skin disorders characterized by transepidermal elimination of dermal tissue components. They can be characterized by the primary or secondary pathogenesis. Primary perforating dermatoses can be divided into four types, according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. The secondary form is also known as acquired perforating dermatosis and designates adult patients with coexisting systemic diseases, regardless of the dermal materials eliminated. The aim of this review is to investigate the potential relationship between Kyrle disease and associated conditions, reporting a rare case of this disease in a patient with chronic kidney disease. CASE PRESENTATION: We report the case of a 55-year-old male patient who presented generalized pruritus and skin lesions on the upper limbs and trunk for about 6 months. Pathological history revealed systemic arterial hypertension and chronic kidney disease (CKD), for which the patient had been on hemodialysis since more than 3 years. CONCLUSION: We reviewed the literature, reporting a rare case of KD in a patient with chronic renal failure on hemodialysis. KD is an acquired dermatologic condition that lacks a standardized treatment approach and can be notoriously difficult to cure. This article provides an overview of the most frequent comorbidities and treatment methodologies previously reported in the literature. If KD is suspected, underlying systemic disorders need to be investigated.