Abstract
[Figure: see text].
Highlights
Omental, myometrial, or placental biopsies were obtained with informed consent from normotensive women with uncomplicated pregnancies and hypertensive women with a clinical diagnosis of preeclampsia
The characteristics of 164 healthy, normotensive pregnant women and 35 women with preeclampsia included in this study are shown in the Table
The prorelaxant effect of kynurenine is confirmed in human arteries and our study provides further translational impetus as we have included a wellcharacterized cohort of women with preeclampsia
Summary
To determine whether kynurenine promotes relaxation of human resistance arteries from normotensive and hypertensive pregnant women and to identify the vascular mechanism of its effects
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