Abstract
During a gating event, the voltage gated potassium channel KvAP undergoes a conformational change in the voltage sensor (helices 1-4), causing the opening of the pore domain (helices 5-6). Throughout this conformational change, the extracellular portion of the pore remains relatively immobile. However, the environment surrounding this part of the pore domain may be altered through changes in lipid packing or tertiary contacts within the channel. In this study, model membranes were used to stabilize KvAP in different gating states and the environment surrounding the pore were probed with ESEEM both in the presence and absence of the voltage sensing domain.
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