Kuru Göz Hastalarında Noninvaziv Değerlendirme: Gözyaşı Ozmolaritesi, Gözyaşı Menisküs Yüksekliği ve Noninvaziv Gözyaşı Kırılma Zamanının Diğer Testlerle İlişkisi

Abstract

Objective: To determine the correlation of non-invasive tests with conventional tear function tests in dry eye patients. Material and Methods: One hundred and twenty-two eyes of 61 patients over 18 years old who applied to Çanakkale Onsekiz Mart University School of Medicine, Department of Ophthalmology with dry eye were included in the study. After general ophthalmological examination including best corrected visual acuity, biomicroscopic examination, non-invasive methods like Ocular Surface Disease Index (OSDI) scoring, tear osmolarity, non-invasive tear break-up time (NI-TBUT) measurement with Scheimpflug topography, meibomography, and measurement of the lower lid meniscus height (TMH) with optical coherence tomography were performed. After non-invasive tests, conventional tear function tests like Schirmer test, TBUT, cornea and conjunctiva staining were applied respectively. Results: A positive correlation was found between NI-TBUT and conventional TBUT (p<0.01 Spearman's rho: 0.473). TBUT was found to be positively correlated with Schirmer test and negatively correlated with corneoconjunctival staining (p<0.01 Spearman's rho: 0.393, rho:-0.418). Schirmer test results were correlated positively with TMH and negatively correlated with OSDI scoring and corneoconjunctival staining (p<0.05 Spearman's rho: 0.181; p<0.05 Spearman's rho:-0.214; p<0.01 Spearman's rho:- 0.394). Tear osmolarity test results and meibomography did not correlate with any test. Conclusion: The non-invasive and objective measurement of NI-TBUT may be a better diagnostic modality than TBUT for dry eye patients. Tear osmolarity and meibomography were not significant for diagnosis of early stage dry eye patients.