Abstract
Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5–8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephadex G-75 column the major activity peak eluted in the size range of 25,000–30,000 daltons. Taken together these results demonstrate that in addition to their well known phagocytic function, Kupffer cells secrete factor(s) that can significantly increase fibrinogen synthesis.
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