Abstract
The Kumada cross-coupling reaction (also occasionally known as the Kharasch cross-coupling reaction) is a nickel- or palladium-catalyzed cross-coupling reaction of a Grignard reagent with an organic halide, triflate, etc. Along with Negishi, Stille, Hiyama, and Suzuki cross-coupling reactions, they belong to the same category of Pd-catalyzed cross-coupling reactions of organic halides, triflates and other electrophiles with organometallic reagents. These reactions follow a general mechanistic cycle as shown on the next page. There are slight variations for the Hiyama and Suzuki reactions, for which an additional activation step is required for the transmetallation to occur.
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