KULIT BUAH NANAS (Ananas comosus (L.) Merr) SEBAGAI ANTIHIPERLIPIDEMIA PADA HAMSTER

Abstract

Ethanol 70% of pineapple fruit skin fraction (Ananas comosus (L) Merr) provides the best activity in handling hyperlipidemia. This is thought to be due to the antioxidant content of flavonoids, saponins and tannins. This study aims to determine the activity of pineapple fruit skin fraction in reducing levels of total cholesterol, triglycerides, LDL and increasing HDL levels of hyperlipidemic hamster blood. Pineapple peel extraction was carried out by multilevel maceration using 3 solvents namely n-hexane, ethyl acetate and 70% ethanol. Phytochemical tests were carried out using thin layer chromatography methods. Syrian male hamsters that have been acclimatized are given a high-fat feed unless normal control. The positive control group was given atorvastatin 0.099 mg / 80gBB and phenofibrate 0.99 mg / 80gBB. Test groups 1, 2, and 3 were given 70% ethanol fraction pineapple rind at a dose of 140, 240 and 340 mg / kgBW while the normal and negative control groups were not treated. The results showed that dose 3 had the highest activity to decrease total cholesterol (59.83%), triglycerides (56.69%), LDL (50.25 %), and increase in HDL levels (50.67%) in the blood of hamsters. It could be concluded that dose 3 of 70% ethanol fraction of pineapple peels had similiar activities with fenofibrate dose 0.99 mg/KgBB and atorvastatin dose 0.167 mg/KgBB.