Kronik Hepatit C Enfeksiyonlu Hastalarda Genotip Dağılımı ve Risk Faktörleri

Abstract

Objective: Hepatitis C virus (HCV) is a common infection around the world and an important public health problem. Determination of HCV genotype is important epidemiologically and for treatment approaches. In this study, the aim was to assess the genotype distribution and associated risk factors for patients monitored at our center in northern Turkey.
 Methods: A cross-sectional study was carried out of patients with confirmed HCV infection. Our study retrospectively assessed 175 patients with chronic hepatitis C diagnosis in the Infectious Diseases clinic from 2016-2019 and with antiviral treatment administered. The samples were tested by type specific genotyping assay. The relationship between demographic characteristics and potential risk factors and genotype was investigated.
 Results: Genotype 1b was identified as the dominant genotype (95%). In 5% of patients, non-1b genotypes were present (genotype 1a, 3 and mixed). Genotype 1b was more common in patients over 50 years of age, while the patients with other genotypes were younger. The most frequent risk factor was identified as surgical intervention history. While young age, transplantation and intravenous drug use were identified as risk factors for development of infection with non-1b genotypes, household HCV contact was significant for genotype 1b.
 Conclusion: In our study, the dominant genotype was identified as genotype 1b. Among the risk factors in our study, the most frequently identified are surgical interventions and dental treatment. The variation in traditional risk factors will cause an increase in non-1b genotypes. We think it is important to correctly analyze these variations in the global struggle with HCV.