Kronik Gastrit ve Tümör Çevresindeki İntestinal Metaplaziler ile Mide Kanserlerinde CDX2 Boyanma Oranlarının Karşılaştırılması

Abstract

Objective: In this study, an immunohistochemical investigation was carried out into CDX2 expression in intestinal metaplasia (IM) that accompanies chronic gastritis in endoscopic biopsies and gastric cancers in resection materials.We aimed to assess differences in the intensity of CDX2 staining between groups and identify the role of CDX2 in determining the risk of cancer. Material and Methods: The endoscopic biopsies taken from 70 stomachs dia gnosed with chronic gastritis and materials resected from 54 stomachs diagnosed with adenocarcinoma have been ex - amined in our laboratory. Results: The mean CDX2 score for the tumors in the resection group was found to be statistically significantly lower compared to that for the complete and incom - plete subgroups in the endoscopic biopsy group (p<0.001). The mean CDX2 score for the comp lete subgroup was statistically significantly lower compared to that for the incomplete subgroup (p<0.05). Conclusion: The mean CDX2 score for IM in endoscopic biopsies is significantly higher compared to that in IM and tumors in the resection group. Mean CDX2 score for complete IM in the resection group is significantly higher than that for incomplete IM and tumor. Mean CDX2 score for incomplete IM and tumor exhibit similar values, which may suggest that the anticarcino - genic effect of CDX2 tends to decrease in incomplete IM and tumor and incomplete IM in an para- cancerous region is in an unstable intermediary position where it is progressing to cancer.