Abstract
This presentation describes an efficient and facile preparation of a series of new spiro-γ-lactam-pyrrolo[2,3-b]quinoline scaffolds. The Ugi adducts obtained via four-component condensation of 2-chloroquinoline-3-carbaldehydes, amines, trans-cinnamic acids and isocyanides underwent metal-free KOtBu-catalyzed bis-annulation processes to afford a diastereomeric mixture of the desired tetracyclic building blocks in moderate to good yields.
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