Korrelation zytologischer und histologischer Befunde an der Cervix uteri

Abstract

A lack of correlation of cytological diagnoses with subsequent histological tissue diagnoses in cervical pathology is caused by either sampling or by interpretation errors. The term sampling error refers to both obtaining cytological material by a cervical smear as well as obtaining tissue samples by surgical procedures such as biopsy or conization. The term interpretation error refers to a lack of correlation as a consequence of the subjective variability in the diagnostic evaluation of cytological, histological or colposcopic findings. This so-called interobserver variability is well known and of considerable significance. Cytological-histological correlation is an important and mandatory method of quality assurance in the cytology laboratory. Lack of correlation can be crucial for the patient because of possible over treatment or under treatment. It can also undermine the relationship between cytopathologists and clinicians. It is therefore crucial to recognize the sources of error presented in this review and to make an effort to resolve discordances by communication and second review.