Korrelation zwischen histologischem Befund und einem Computer-assistierten Detektionssystem (CAD) für die Mammografie

Abstract

PURPOSE: To assess the sensitivity and specificity of a wavelet transformation-based computer-assisted detection system (CAD) for mammography after film digitizing and data compression. MATERIALS AND METHODS: 128 one-sided mammograms of 128 patients with 135 histological proven lesions were evaluated by the CAD System (66 malignant lesions, 69 benign lesions). Two groups were enrolled and analysed: one group with calcifications only and one group with masses and calcifications. None of the lesions were palpable. After stereotactic wire placement the histological specimens were obtained by open breast biopsy. The mammograms were digitized and afterwards analysed by the CAD system integrated in the mammography system. RESULTS: CAD correctly detected 95.4 % of the malignant lesions with microcalcifications only and 81.8 % of the malignant lesions with mammographic masses and calcifications. Overall, 90.9 % of malignant lesions were detected. With respect to all benign lesions CAD correctly did not mark 50 % of lesions with microcalcifications only and 44 % of masses with calcifications. The specificity was 50.7 %. CONCLUSION: With regard to its high sensitivity the evaluated CAD system is useful as a supporting method in mammographies. Because of its low specificity every CAD mark must be cross-checked by a skilled mammography examiner.