Abstract
Female infertility and subfertility have been increasing in prevalence worldwide. One contributing factor is ovarian function, which is highly age-dependent. Korean red ginseng is widely used as an herbal medicine and has many beneficial properties. We aimed to determine the effect of the Korean red ginseng saponin fraction (KRGSF) on ovarian function in female C57BL/6 mice. Ovaries were isolated from 6- and 12-month-old female mice and treated with KRGSF, and then RNA was extracted and microarray analysis was performed. The expression of key genes was subsequently verified using quantitative RT-PCR. Aging markedly increased the expression of genes encoding oxidative stress factors and NLRP3 inflammasome components, but the expression of these genes was significantly reduced by KRGSF treatment. Thus, the reduction in ovarian health with age is associated with greater oxidative stress response and inflammation, but KRGSF treatment may limit these age-related changes.
Highlights
Average life expectancy has increased worldwide alongside economic growth and the progression of medical technology, and this increase in life expectancy, along with cultural and social factors, has led people to marry and give birth later than previously [1,2,3,4]
The Korean red ginseng was extracted with water at about 95 ◦ C for 2 h, and this process was repeated three times
A saponin fraction was prepared from 6-year-old Korean red ginseng
Summary
Average life expectancy has increased worldwide alongside economic growth and the progression of medical technology, and this increase in life expectancy, along with cultural and social factors, has led people to marry and give birth later than previously [1,2,3,4]. This trend has emphasized the effect of aging on the fertility of otherwise healthy couples. It is considered to be an imbalance between the production of ROS and their removal by protective mechanisms, which can cause inflammation. Isocitrate dehydrogenase (Idh1) catalyzes the decarboxylation of isocitrate to form α-ketoglutarate and CO2 , and generates
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