Abstract
Background: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells. Methods: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells. Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells. Conclusion: Our results show that KRG can be used as a possible anticancer drug for patients with CRC
Highlights
Colorectal cancer (CRC) is the most commonly occurring cancer worldwide [1]
We observed the morphology of HT29 and DLD-1 cells treated with Korean Red Ginseng (KRG) extract by light microscopy
We found that cells treated with KRG extract showed significantly higher expression of Noxa than control cells (Figure 2C)
Summary
Colorectal cancer (CRC) is the most commonly occurring cancer worldwide [1]. Treatment options for CRC usually include surgery, radiation therapy, and chemotherapy. Korean Red Ginseng (KRG) is a traditional herbal medicine that has been used to treat various diseases such as cancer, Alzheimer’s disease, anti-inflammatory diseases, and diabetes [5,6,7]. The anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
