Abstract
Streptomycetes are the most important source for antibiotics. One representative species is Streptomyces pristinaespiralis–the producer of pristinamycin. Pristinamycin biosynthesis is governed by a complex signalling cascade consisting of seven different transcriptional regulators. Understanding the signalling cascade can help to optimize antibiotic production processes in general but also allows to targetedly activate silent gene cluster expression in order to find new antibiotics.
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