Kolorektal kanserlerin yeniden evrelemesinde F-18 FDG PET/BT’nin önemi

Abstract

Aim: The aim of the present study is to investigate the impact of F-18 FDG PET/CT in the restaging of colorectal cancer in patients with suspected recurrence. Thus, PET/CT findings were compared with that of CT. In addition, the correlation between serum CEA levels and PET/CT and CT findings was investigated. Furthermore, the role of PET/CT in treatment response among patients who were treated after restaging was assessed.
 Material and Method: In this retrospective study, a total of 102 patients operated for colorectal cancer (63 female, 39 male, mean age 65.81±4.63 years) were investigated. F-18 FDG PET/CT scans were acquired in all patients. The findings of PET/CT were compared with that of concurrent CT, and also with CEA levels.
 Results: In the study, the success rates of PET/CT and CT in detecting pathologic lesions in colorectal cancer cases with suspected recurrence were 98% and 64.7%, respectively. In 34 cases, pathologic lesions were detected with PET/CT, while CT showed no recurrence. The lesions of 68 cases out of 70 with high CEA levels were localized by means of PET/CT, whereas pathology was observed by CT in only 45 cases. Thus, PET/CT was considered more successful than CT in detecting recurrence. In the liver where lesion was localized the most, the sensitivity and specificity of PET/CT were 88% and 92%, respectively, while the sensitivity and specificity of CT were 80% and 76%, respectively. 
 Conclusion: In the light of findings, our study suggested PET/CT as a valuable imaging tool for restaging and treatment response assessment in colorectal cancer cases with suspected recurrence.