Kolorektal kanser nedeniyle opere olan hastalarda ameliyat öncesi CA 19-9 ve CEA düzeyleri ile tümörün histopatolojisi arasındaki ilişki

Abstract

Abstract
 Aim: Colorectal cancer is a serious disease that can result in death. The fact that cancer markers and early diagnosis increase the effectiveness of treatment reveals the need for multidimensional research on this subject. TNM classification of colorectal cancer is shows the prognosis. In our study, the relationship between preoperative CEA and CA 19-9 values and histopathology of tumor and preoperative predictive value of tumor markers in colorectal cancer patients were investigated.
 Materials and Methods: 153 patients diagnosed with colorectal cancer were included in the study. The histopathological data in the resection materials of the patients who were operated by General Surgery Department were collected from the pathology reports. Clinical data were collected by retrospective scanning of patient files. 
 Results: The mean age of the patients was 64 (± 11.39) years. 51.6% were male and 48.4% were female. CEA was found to be positive in 35.3% of the patients, while this rate was 20.9% for CA 19-9. In our study, CEA and CA 19-9 positivity were significantly correlated with TNM stage of tumor, depth of invasion, lymphovascular invasion, perineural invasion, nodal involvement and metastasis. In addition, the mean age of CA 19-9 positive cases was significantly higher than the negative ones. The mean tumor size of CEA positive cases was significantly higher than the negative ones. 
 Conclusion: CEA and CA19-9 are valuable both in demonstrating advanced stage tumors and in detecting malignancy in tumors detected in advanced ages. Since survival decreases as the stage progresses, positive CEA and CA19-9 values are both associated with worse prognosis.