Abstract
During pregnancy and the postpartum period, the mother-to-be is faced with several challenges concerning the hemostatic system. Physiological changes in hemostasis—which generally lead to a hypercoagulable state—protect the pregnant woman against severe bleeding during delivery on the one hand, but, on the other, significantly increase the risk of venous thromboembolism during pregnancy and the postpartum period. Preexisting, hereditary or acquired coagulopathies (thrombophilia and hemophilia) can additionally increase the risk of potentially life-threatening hemostasis complications, specifically in the peripartum period, and therefore require a timely and specific diagnosis. The following article reviews the significance of hemostasis testing during pregnancy, addresses the indications and applications of different laboratory hemostasis assays and discusses the effects of physiological changes during pregnancy on the test results and their interpretation.
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