Abstract
BackgroundThe global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children’s growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government.Methods/designFrom seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life.DiscussionWith this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients.Trial registrationNCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.
Highlights
The global prevalence of chronic kidney disease (CKD) is increasing
With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients
We introduce a pediatric cohort study in Korea, KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, ten-year prospective, observational cohort study of pediatric CKD that was launched in 2011 as a sub-cohort of KNOW-CKD, which was funded by the Korean government [6]
Summary
The global prevalence of chronic kidney disease (CKD) is increasing. Whereas diabetic nephropathy and hypertensive nephropathy are major causes of CKD in adults, congenital anomalies of kidney and urinary tract (CAKUT) are the most common causes of CKD in children. The life expectancy of pediatric CKD patients is much longer than that of adult CKD patients; pediatric patients require a more aggressive approach to slowing the progression of CKD and reducing its complications [16,17,18,19,20]. The majority of these studies are from Western countries with small proportions of Asian individuals
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