Abstract
The goal of endodontic treatment is the debridement and removal of the microbial ecosystem associated with the disease process. The need for root canal disinfectants increases especially in those cases where infection is resistant to the regular treatment and the outcome of endodontic therapy is often compromised. Therefore, it is of interest to document the known effectiveness of silver nanoparticle based root canal disinfectants with other root canal disinfectants on microbial load reduction during root canal disinfection. Known data shows that the overall risk of bias for the selected studies was moderate. Silver nanoparticle based root canal disinfectants showed superior reduction of microbial counts in majority of the studies. This data is limited to vitro studies with no clinical information to validate the use of antimicrobial properties of silver nanoparticles used as root canal disinfectant.
Highlights
One of the objectives of a successful root canal treatment is to eliminate or reduce the presence of intra-‐canal bacteria
Total sixteen studies, which fulfilled the inclusion criteria, were included in this systematic review. (Figure 2) No clinical reports concerning the application of antimicrobial silver nanoparticles in endodontics was found
Till date there are no clinical trials done which have checked the efficacy of silver nanoparticles when used as root canal disinfectant either in the form of root canal irrigants or intracanal medicament
Summary
One of the objectives of a successful root canal treatment is to eliminate or reduce the presence of intra-‐canal bacteria. An infected root canal system is a unique niche for the selective species of microorganisms [1]. Apical periodontitis, which persists after root canal treatment, possesses more complex etiological and therapeutic situation [3]. Especially Gram-positive facultative, possess greater resistance to antimicrobial agents used during endodontic treatment than anaerobes. Another important factor, which has become evident during the last few years, is that microbes in the root canals can grow as planktonic cells or in aggregates, co-aggregates, but they can form biofilms consisting of a complex network of different microorganisms [4,5]. Biofilms are composed of micro colonies of bacterial cells that are distributed in a matrix
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