Knowledge-based classification and tissue labeling of MR images of human brain

Abstract

Presents a knowledge-based approach to automatic classification and tissue labeling of 2D magnetic resonance (MR) images of the human brain. The system consists of 2 components: an unsupervised clustering algorithm and an expert system. MR brain data is initially segmented by the unsupervised algorithm, then the expert system locates a landmark tissue or cluster and analyzes it by matching it with a model or searching in it for an expected feature. The landmark tissue location and its analysis are repeated until a tumor is found or all tissues are labeled. The knowledge base contains information on cluster distribution in feature space and tissue models. Since tissue shapes are irregular, their models and matching are specially designed: 1) qualitative tissue models are defined for brain tissues such as white matter; 2) default reasoning is used to match a model with an MR image; that is, if there is no mismatch between a model and an image, they are taken as matched. The system has been tested with 53 slices of MR images acquired at different times by 2 different scanners. It accurately identifies abnormal slices and provides a partial labeling of the tissues. It provides an accurate complete labeling of all normal tissues in the absence of large amounts of data nonuniformity, as verified by radiologists. Thus the system can be used to provide automatic screening of slices for abnormality. It also provides a first step toward the complete description of abnormal images for use in automatic tumor volume determination.