Abstract
The side effect profile of NSAIDs is well-established. For prevention of NSAID-related ulcers, the evidence suggests that misoprostol and PPIs (proton pump inhibitors) are superior to H2RAs (histamine-2-receptor-antagonists). Current guidelines recommend use of the lowest possible NSAID dose, as well as consideration of the patients' gastrointestinal and cardiovascular risk profile.
Highlights
EpidemiologyNon-steroidal anti-inflammatory drugs (NSAIDs), are Citation: Duong N, Lee A, Lewis JH (2018) Knowledge and Attitudes of Internal Medicine Trainees’Co-Prescribing Patterns of Gastroprotective Agents in Patients Taking Long-Term Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Despite guidelines regarding the use of gastroprotective agents in patients on NSAID therapy, this practice is still underutilized clinically
Increased education and continued awareness concerning NSAID-related GI complications should continue throughout training
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs), are Citation: Duong N, Lee A, Lewis JH (2018) Knowledge and Attitudes of Internal Medicine Trainees’. Co-Prescribing Patterns of Gastroprotective Agents in Patients Taking Long-Term Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). It has been estimated that 25% of chronic NSAID users for arthritis may develop endoscopic evidence of ulcers [3,4,5]. 5% of these ulcers bleed or perforate, gastrointestinal bleeding accounts for 200,000-400,000 admissions in the U.S per year [9]. Over 100,000 admissions are a direct result of bleeding ulcers due to NSAID use [10,11]. Current guidelines recommend use of the lowest possible NSAID dose, as well as consideration of the patients’ gastrointestinal and cardiovascular risk profile
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