Abstract
As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer.
Highlights
Ovarian cancer is a common gynecological malignancy and remains one of the leading causes of cancer‐related mortality among females [1]
S100A11 is a member of the S100 protein family, and is widely expressed in human tissues
Overexpression of S100A11 has been identified in a variety of human cancer types and elevated S100A11 expression is closely associated with tumor progression [12]
Summary
Ovarian cancer is a common gynecological malignancy and remains one of the leading causes of cancer‐related mortality among females [1]. The expression of a variety of proteins can change during the progression of cancer. A previous study demonstrated that increased S100A11 expression is correlated with the metastasis of gastric cancer and poor overall disease prognosis [9]. Decreased expression of S100A11 has been reported in bladder cancer, and downregulation of S100A11 has been associated with bladder cancer progression [10]. The role of S100A11 in ovarian cancer remains unclear. The aim of the present study was to analyze the levels of S100A11 in ovarian cancer cells. The effects of S100A11 knockdown on ovarian cancer cell growth and invasion were investigated in order to determine the function of S100A11 in ovarian cancer progression
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