Abstract
DNA repair mechanisms play a central role in the development of therapy resistance, but still remain poorly understood and exploited as targets for anticancer therapy. Based on a yeast model microtiter assay described previously, we identified several important pathways for the processing of DNA lesions from cisplatin and X-rays. In this study, we have targeted corresponding DNA repair pathways in a human H&N SCC cell line system for modulation and enhancement of chemoradiosensitivity.
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