Abstract
Purpose: Imaging plays an important role in determining structural disease severity and potential suitability of patients recruited to DMOAD trials. From a structural perspective, it is knees with KL grades 2 and 3 that are commonly considered eligible for inclusion. While MRI-based phenotypic characterization of large cohort data is not available to date, it has been suggested that there may be 3 main structural phenotypes in OA, i.e., inflammation, meniscus/cartilage and subchondral bone. These may progress differently and represent distinct tissue targets for DMOAD approaches.
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